Endocrine Abstracts

Primary hyperparathyroidism (PHPT) is a common reason for referral to the endocrinology team. We aimed to estimate the prevalence of associated vitamin D deficiency and osteoporosis, to evaluate the usefulness of imaging studies in identifying a parathyroid adenoma prior to surgery and to assess response to surgical treatment in the setting of a District General Hospital.We searched our outpatient clinic letters and identified 64 patients diagnosed with ...

An 18-year-old female presented to acute services with polydipsia and lower back pain. Routine blood tests revealed hypercalcaemia 3.67 mmol/l with significantly raised parathyroid hormone levels 2986 ng/l (10–65), alkaline phosphatase (ALP) 3330 IU/l (30–130), and low vitamin D 10.3 nmol/l (50–220). A CT scan revealed a 3.5 cm parathyroid adenoma and very osteopenic bones with multiple lucencies in keeping with primary hyperparathyoidism. The parathyroid subtra...

A 51-year-old Afro-Caribbean lady with a history of primary hyperparathyroidism, type 2 diabetes and hypertension was admitted with confusion. Her medication at the time included five anti-hypertensives.She was treated for an infection but despite a long course of antibiotics she remained confused with visual hallucinations and aggression.She was noted to have resistant hypertension with systolic blood pressures over 220 mmHg and p...

There are very limited data on long-term mortality in pituitary ACTH dependent Cushing’s disease (CD).We report on our data from Stoke-on-Trent, UK, spanning 50 years and provide a meta-analysis of six other reports which addressed mortality of CD. Case records of 60 CD patients from 1958-31 Dec 2009 from Stoke-on-Trent were reviewed. The standardised mortality ratio (SMR) overall and separately for patients in remission and having persistent diseas...

An incidentaloma is a mass lesion found by chance on imaging for a reason unrelated to the site of the lesion. Adrenal incidentalomas, as a result of advances in imaging technology, have an increased incidence, especially in the aging population. An endocrine referral is advised to determine if the lesion is functional, to exclude malignancy and offer on going appropriate follow-up.Aim: To assess the incidence and audit the management of adrenal incident...